- Dance Companies, North Wilkesboro
- Data Communications Service, Equipment, Supplies & Sales, North Wilkesboro
- Day Spas, North Wilkesboro
- Decorating & Designing Services, North Wilkesboro
- Delicatessen Grocers, North Wilkesboro
- Delicatessen Restaurants, North Wilkesboro
- Dentists, North Wilkesboro
- Department Stores, North Wilkesboro
- Dermatologists, North Wilkesboro - Skin Doctors, Physicians & Surgeons (Dermatology)
- Developmental Children Services, North Wilkesboro
- Dialysis Clinics, North Wilkesboro - Kidney Dialysis Centers
- Diesel Engine, North Wilkesboro
- Disability And Social Security Attorneys & Lawyers, North Wilkesboro
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- Discount Stores, North Wilkesboro - Clothing, Grocery, Furniture, Etc
- Dispensing Machines, North Wilkesboro
- Divorce & Family Law Attorneys & Lawyers, North Wilkesboro
- Doctors, Physicians & Surgeons, North Wilkesboro
- Donuts, North Wilkesboro
- Doors & Door Frames, North Wilkesboro - Exterior, Interior, French, Front Entry, Patio, Storm, Garage & Sliding Glass Doors
- Drinking Establishments, North Wilkesboro
- Drug Screening Services, North Wilkesboro
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, North Wilkesboro
- Dry Cleaning & Laundry, North Wilkesboro - Dry Cleaners
- Drywall Contractors, North Wilkesboro - Drywall Repair & Installation Services
- Durable & Non Durable Goods & Products, North Wilkesboro
- Durable Goods & Products, North Wilkesboro
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