- Sand Gravel & Aggregate, Jefferson
- Senior Citizens Service & Health Organizations, Jefferson
- Sheet Metal Contractors, Jefferson - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Jefferson
- Shopping & Shopping Services, Jefferson
- Siding Contractors, Jefferson - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Jefferson
- Social Service Organizations Volunteer Services, Jefferson
- Social Services & Welfare, Jefferson
- Societies & Foundation Associations, Jefferson
- Special Events & Party Supply Rental, Jefferson
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- Specialty Animal Services, Jefferson
- Specialty Stores, Jefferson
- Sporting Goods Equipment Rental, Jefferson
- Staffing & Support Services, Jefferson
- State Government, Jefferson
- Steak House Restaurants, Jefferson
- Substance Abuse Clinics, Jefferson - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Support Services, Jefferson
- Surveyor Services, Jefferson - Surveying Service
- Surveyors, Jefferson
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