- Sandwich Shop Restaurants, Lillington
- Satellite Technology & Space Research, Lillington
- Savings Banks, Lillington
- Scrap & Waste Materials, Lillington
- Seafood Restaurants, Lillington
- Secondary Schools, Lillington
- Security Brokers & Dealers, Lillington
- Senior Citizens Service & Health Organizations, Lillington
- Septic Tank Pumping & Cleaning, Lillington - Septic Systems
- Sheet Metal Contractors, Lillington - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Lillington
- Shopping & Shopping Services, Lillington
- Siding Contractors, Lillington - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Lillington
- Sleep Doctors, Lillington - Specialists, Physicians & Surgeons (Sleep Medicine)
- Social Clubs & Organizations, Lillington
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- Social Services & Welfare, Lillington
- Soil Scientists, Lillington
- Sound Systems, Microphones & Equipment, Lillington
- Special Events Photographers, Lillington
- Specialty Animal Services, Lillington
- Specialty Stores, Lillington
- Sports Bars & Lounges, Lillington
- Staffing & Support Services, Lillington
- State Government, Lillington
- State Highway Patrol, Lillington
- State Law Enforcement, Lillington
- Stocks & Bond Brokers, Lillington
- Substance Abuse Clinics, Lillington - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Substance Abuse Services, Lillington
- Surveyor Services, Lillington - Surveying Service
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