- Sandblasting, Manteo - General Contractors
- Sandwich Shop Restaurants, Manteo
- Savings Banks, Manteo
- Seafood Restaurants, Manteo
- Secondary Schools, Manteo
- Security Brokers & Dealers, Manteo
- Septic Tank Pumping & Cleaning, Manteo - Septic Systems
- Septic Tanks & Systems, Manteo - Wholesale, Dealers & Suppliers
- Sewage Septic Service, Manteo
- Sewing & Yarn Stores & Supplies, Manteo
- Shopping & Shopping Services, Manteo
- Sightseeing Tours, Manteo
- Signs, Manteo
- Snacks & Desserts, Manteo
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- Social Clubs & Organizations, Manteo
- Social Services & Welfare, Manteo
- Soda Fountain Shops, Manteo
- Specialty Goods Storage, Manteo
- Specialty Stores, Manteo
- Specialty Vehicle Rental & Leasing, Manteo
- Sportswear Clothing Stores, Manteo - Sports Clothes
- State Government, Manteo
- Stocks & Bond Brokers, Manteo
- Structural Engineer, Manteo
- Suicide Prevention Service & Counseling, Manteo
- Surveyor Services, Manteo - Surveying Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Manteo
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