- Obstetricians & Gynecologists, Mebane - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Mebane
- Off Road Vehicles Parts & Accessories, Mebane
- Office Supplies, Equipment & Office Furniture Stores, Mebane
- Oil & Gas Companies, Mebane
- Oil And Petroleum Products, Mebane
- Oil Change & Lubrication, Mebane - Auto Oil & Quick Lube
- Oncologists, Mebane - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Mebane - Eye Doctors, Physicians & Surgeons (Ophthalmology)
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- Optical Stores - Eyeglasses, Lenses & Sunglasses, Mebane
- Optometrists, Mebane - Eye Doctors, Physicians & Surgeons (Optometry)
- Optometry Clinics, Mebane - Eye Clinics
- Ornamental Nursery, Mebane
- Ornamental Nursery Services, Mebane
- Orthodontist, Mebane - Teeth Straightening, Invisalign & Dental Braces
- Other Building Materials & Supplies, Mebane
- Outdoor Equipment & Accessories, Mebane
- Ownership Organizations, Mebane
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